Controlled Delivery Formulations

Lyoprotected nanosphere formulations for paclitaxel controlled delivery.

The preparation and technological characterization of nanosphere formulations (NS) containing the anticancer drug paclitaxel (PTX) are reported. Poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) nanospheres (NS) were prepared by a solvent displacement method. They showed a mean particle size in the range 150-300 nm, with a high homogeneity (polydispersity index < 0.3). For long term sta...

Controlled Release Gel Formulations

Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermoreversible poloxamer gels, which are suitable for novel drug delivery applications. In particular co-solvents (DMSO, ethanol), mucoadhesive polymers (chitosan, alginate) and salt...

Novel delivery system for natural products: Nano-curcumin formulations

Objective: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). A wide range of studies have been conducted on the physicochemical traits and pharmaco...

Nanovaccine Delivery Systems in Vaccine Formulations

The important biological molecules such as polysaccharides, proteins, allergens and Pathogen Associated Molecular Patterns (PAMPs) are of nanometer in size. Hence, the size, charge, hydrophobic properties will influence their effects on the immune system by way of specific and varied response. Vaccines play a pivotal role in disease containment and prevention. One of the bottle necks is the vac...

Injectable Drug Delivery 2013: Formulations Focus